![]() ![]() There have been rare clinical case reports of adverse side effects after taking chromium picolinate supplements.įor example, a report published in the journal The Annals of Pharmacotherapy described the case of a 33-year-old woman who developed kidney failure, liver damage, and anemia after taking 1,200 to 2,400 micrograms of chromium picolinate (approximately six to 12 times the recommended daily allowance) for five months for weight loss. There is very little information, however, about the safety of long-term use of chromium. The Food and Nutrition Board of the Institute of Medicine has acknowledged the possibility of negative impact from high oral intakes of trivalent chromium, but in the absence of evidence to suggest otherwise, has not set a maximum limit for ingestion. 2Ĭritics say that the scientists used unrealistically high doses and that administering chromium to cells in test tubes is not the same as taking chromium supplements orally. However, there is no evidence of DNA damage from trivalent chromium in living organisms. Other laboratory studies using cell cultures have suggested chromium picolinate causes oxidative stress and DNA damage. The researchers added high concentrations of chromium picolinate, chromium chloride or chromium nicotinate to hamster cells in culture and found that only chromium picolinate could damage the genetic material of the hamster cells. In 1995, a study headed by Diane Stearns, Ph.D., at Dartmouth College, generated controversy about the safety of chromium picolinate. High blood sugar related to steroid useĬurrently, there is not enough evidence to support the use of chromium supplements for these uses.High blood cholesterol caused by medication.Other uses for chromium picolinate include the prevention or treatment of:
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